AMINO ACID DERIVATIVES & UNCA’S

Senn Chemicals is one of the largest suppliers of amino acid derivatives. The large scale production of these products using optimized conditions allows for control of quality as well as cost. As a peptide producer, we understand the importance of the purity of the amino acid derivatives used in peptide synthesis and how purity can affect the cost of the final peptide. Frequently, impurities in amino acid derivatives can be carried through the synthesis and contaminate the final peptide product. Consequently, the amino acid derivatives produced by Senn Chemicals are of the very highest quality.

An example of this situation is the production of Fmoc-amino acids. It is not unusual for Fmoc amino acids to contain non-negligible amounts of Fmoc-beta-alanine and Fmoc-beta-alanine-AA. Impurities in the final peptide arising from these contaminants are often extremely difficult to remove, resulting in the lowering of the yield and increasing the cost. Senn Chemicals has developed processes to overcome these issues in order to guarantee a streamlined peptide synthesis with our high quality amino acid derivatives.

Non-Natural Amino acid derivatives:

Senn Chemicals is also a major supplier of protected and unprotected non-natural amino acids. A variety of synthetic procedures can be carried out to respond efficiently to your needs in this field.

One of the major challenges of using peptides as therapeutics is their susceptibility to enzymatic proteolysis. Replacement of certain amino acid residues by small organic moieties (building blocks) or unnatural amino acids often leads to peptides with enhanced resistance to proteolysis. Therefore, such agents are in increasing demand by researchers in peptide or mimetic drug design.

NCAs and UNCAs:

Amino acid N-carboxy anhydrides (NCAs) and Urethane protected NCAs (UNCAs) are valuable tools for the synthesis of polyamino acids (NCAs) and peptides (UNCAs). These molecules are activated and protected (in the case of UNCAs), and react with nucleophiles to provide amino acid derivatives with CO2 as the only co-product. Senn Chemicals has developed proprietary technologies which allow for the production of NCAs and UNCAs in the laboratory, pilot plant, or production scales.  Senn Chemicals produces a wide range of UNCAs from natural and non-natural amino acids in large quantities. We also produce amino acid NCAs in large quantities to highly exacting specifications suitable for polymerizations.